When FZP-CBD reached the intestinal digestion stage, a burst release was observed potentially due to the presence of trypsin in the SIF (29). This enabled flexible zein to be rapidly decomposed which facilitated the release and absorption of CBD. The experimental results showed that FZP-CBD could protect most of the CBD from being released in the stomach, and then control its release in the intestines and promote the absorption of CBD in the small intestine, thus improving the bioavailability of CBD. Using PC12 cells as in vitro cell lines, the cytotoxicity of CBD dispersion and FZP-CBD was studied by CCK8.
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- This is based on the concept of plant molecule synergy, better known among cannabis enthusiasts and professionals as the entourage effect.
- For example, while the research is still scarce and preliminary, studies have found that CBD shows promise in the treatment of cocaine and methamphetamine addiction.
It’s unclear whether this is related to the actual substance or to impurities left behind during poorly regulated manufacturing processes. Likewise, poison control centers received more than 2,000 cases of poisoning from delta-8 between January 2021 and February 2022, including one pediatric case that resulted in death. Moreover, CBD may cause hypotension and dizziness, which in certain instances could lead to falls and injuries [118].
CBD attenuates drug seeking with effects that far outlast treatment
Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic characteristics of glioma and the lack of breakthroughs in treatment modalities, the prognosis for most patients remains poor. In recent years, cannabidiol (CBD) has garnered widespread attention and research due to its anti-tumoral, anti-inflammatory, and neuroprotective properties. This review comprehensively summarizes the preclinical and clinical research on the use of CBD in glioma therapy, as well as the current status of nanomedicine formulations of CBD, and discusses the potential and challenges of CBD in glioma therapy in the future. Nanodelivery system is a technology to deliver drugs or other biomolecules to specific cells or tissues through a carrier called nanoparticles.
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Because CBD may have a calming effect, it may also hold promise in treating sleeping difficulties. Sleep is a critical component of mental health and well-being, yet the Centers for Disease Control and Prevention (CDC) reports that a third of U.S. adults do not get the recommended amount of sleep each night. This is problematic since not getting enough sleep is linked to health conditions such as depression, type 2 diabetes, obesity, and heart disease. According to the National Institute of Mental Health, depression is one of the most common mental disorders in the U.S., affecting an estimated 17.3 million adults each year. Effective treatments are available, which include psychotherapy and medication, although interest in complementary and alternative treatments has also grown in recent years. Kristi is a freelance writer and mother who spends most of her time caring for people other than herself.
Packing your hurricane go bag? Make provisions for your health
Its legal status in countries is something for national legislators to decide. Some countries have eased regulations around cannabidiol, to consider products containing CBD to be medical products. These include Australia, Canada, Switzerland, the United Kingdom, and the United States of America.
Effects of CBD on tobacco-related addictive behaviors
In addition to mental health benefits, some research indicates that CBD might be helpful for reducing pain, relieving nausea, and treating inflammation. The World Health Organization also suggests that CBD may be helpful for treating conditions such as Alzheimer’s disease, arthritis, cardiovascular disease, and diabetes. While promising, more research is needed to understand how CBD might be utilized for the treatment of substance use disorders. Because marijuana can be addictive, particularly when it is used heavily and at high doses, you might wonder if CBD addiction is also possible. Products containing CBD have grown in popularity in recent years, found in everything from gummy supplements to post-workout smoothies to CBD-infused pillows.
- However, CBD products containing more than 0.3% THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws.
- To investigate the biocompatibility of FZP-CBD, the experiments used PC12 cells as a cell model.
- While CBD does not appear to be reinforcing on its own, its impact on cannabis-related addictive behaviors in animal models remains unclear.
- Additionally, studies show that pure CBD has no known psychoactive effect in its pure form and is considered to be safe and non-intoxicating.
In the intervention group, the most common AE of any grade was somnolence (22.0%), followed by a decreased appetite (19.5%) and pyrexia (15.3%). In the controls, upper respiratory tract infection (11.8%), is cannabidiol addictive diarrhea (10.9%), and pyrexia (10.2%) were the most common AEs. The overall percentage of any grade AEs was higher in the CBD group than in the control group (9.7% vs 4.0%) (eFigure 1 in Supplement 1).